PP6012 Toxicology Online Theory Exam
Instruction to Candidates:
- Please log onto the Moodle site PP6012. At 2pm go to the Assessment section. Open the word file called‘PP6012 Exam-1st June 2020’.
- You are presented with the exam paper.Please any one question from section A and any two of the five questions from section B. Each question in a section will carry carries equal marks.
- Open a new word document page for each question on the above document, write your student numberand the question number as indicated.
- Type your answer into this document. You may insert into the document pictures of hand-drawn figures or writing taken with your mobile.
- The exam starts at 2pmand finishes at 5pm. Save the word document using your student number as the file name.You need toupload this file onto the Turnitin link by 5.30pm.
- Upload onto the “PP6012Examination Submission-1stJune 2020” Turnitin site in the Assessment section of the PP6012Moodle site.
- If there are any queries please ask at the beginning and end of the exam. Otherwise text your query on ‘teams’. I will be monitoring from 2pmto 5.30pm.
- The exam paper is shown below
Additional open-book regulations
- Do not copy and paste text or figures from another source (this may incur plagiarism, an academic breach and the assessment can potentially be invalidated).
- Do not attempt to submit the paper more than ONCE on Turnitin to check the similarity levels.
- Only as an approximate guide consider 1000-1500 words for each question. You will not be penalised if you exceed these limits.
Examination Question Paper
Module Code: | PP6012 |
Component No: | 1 | Paper Type: | Exam |
Module Title: | Toxicology |
Term | Term 2 |
Level: | 6 |
Credits: | 30 |
Date: | 1st June 2020 | Time: | 2pm |
Duration: | 3hours |
| | | | | |
PP6012 Toxicology Online Theory Exam Questions
Students are required to answer one question from Section A (40%) and ANY Two questions from Section B (60%).
All questions carry equal marks.
Section A
- Review the role of genetic polymorphism in the metabolism and toxicity of three named compounds.
- Discuss the importance the regulatory process in the development of a new drug.
- Review the importance of the generation of reactive metabolites in xenobiotic mediated toxicity.
- A patient was given a 300mg dose of drug by bolus intravenous injection and plasma concentration determined as displayed in the table below.
Time (h) | 0.5 | 1.0 | 2.0 | 3.0 | 4.0 | 5.0 | 6.0 | 7.0 | 8.0 | 9.0 | 10.0 |
Drug Concentration (mg/l) | 15 | 13.6 | 11.6 | 10.4 | 9 | 7.8 | 6.7 | 5.8 | 5.2 | 4.5 | 3.6 |
- Plot the data on the graph paper provided [30 Marks].
- Given that kel = slope x 2.303, t1/2 = 0.693/ kel, VD = dose/Co ,
Kel = Co/AUC and Kel = CLtot/ VD determine kel[10 Marks], t1/2 [5 Marks], VD [5 Marks], Co [5 Marks], AUC [10 Marks] and CLtot[5 Marks]
- Comment on the significance of the pharmacokinetic profiles of drugs to their toxic actions [30 Marks]
Section B
2. Critically review the stages in a traditional clinical trial and discuss how these can be modified when there is a need to quickly bring new drugs to the public.
3. Evaluate the factors and mechanisms which make the liver a target for some toxic xenobiotics and how this could be assessed.
4. Using at least two examples, review the role of toxicity testing in the development of a new drug.
5. Review the role xenobiotics play in transforming a normal cell into a cancer cell.
6. Using specific examples review the role of heavy metals in environmental toxicology.
End of Paper
PP6012 Toxicology Online Theory Exam
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