PP6012 Toxicology Online Theory Exam

PP6012 Toxicology Online Theory Exam

Instruction to Candidates:

1. Please log onto the Moodle site PP6012. At 2pm go to the Assessment section. Open the word file called‘PP6012 Exam-1st June 2020’.
2. You are presented with the exam paper.Please any one question from section A and any two of the five questions from section B. Each question in a section will carry carries equal marks.
3. Open a new word document page for each question on the above document, write your student numberand the question number as indicated.
4. Type your answer into this document. You may insert into the document pictures of hand-drawn figures or writing taken with your mobile.
5. The exam starts at 2pmand finishes at 5pm. Save the word document using your student number as the file name.You need toupload this file onto the Turnitin link by 5.30pm.
6. Upload onto the “PP6012Examination Submission-1^stJune 2020” Turnitin site in the Assessment section of the PP6012Moodle site.
7. If there are any queries please ask at the beginning and end of the exam. Otherwise text your query on ‘teams’. I will be monitoring from 2pmto 5.30pm.
8. The exam paper is shown below

Additional open-book regulations

1. Do not copy and paste text or figures from another source (this may incur plagiarism, an academic breach and the assessment can potentially be invalidated).
2. Do not attempt to submit the paper more than ONCE on Turnitin to check the similarity levels.
3. Only as an approximate guide consider 1000-1500 words for each question. You will not be penalised if you exceed these limits.

Examination Question Paper

PP6012 Toxicology Online Theory Exam Questions

Students are required to answer one question from Section A (40%) and ANY Two questions from Section B (60%).

All questions carry equal marks.

Section A

1. Review the role of genetic polymorphism in the metabolism and toxicity of three named compounds.
2. Discuss the importance the regulatory process in the development of a new drug.
3. Review the importance of the generation of reactive metabolites in xenobiotic mediated toxicity.
4. A patient was given a 300mg dose of drug by bolus intravenous injection and plasma concentration determined as displayed in the table below.

1. Plot the data on the graph paper provided [30 Marks].
2. Given that k_el = slope x 2.303, t_1/2 = 0.693/ k_el, V_D = dose/C_o ,

K_el = C_o/AUC and K_el = CL_tot/ V_D determine k_el[10 Marks]_, t_1/2 [5 Marks], V_D [5 Marks]_, C_o [5 Marks], AUC [10 Marks] and CL_tot[5 Marks]

1. Comment on the significance of the pharmacokinetic profiles of drugs to their toxic actions [30 Marks]

Section B

2. Critically review the stages in a traditional clinical trial and discuss how these can be modified when there is a need to quickly bring new drugs to the public.

3. Evaluate the factors and mechanisms which make the liver a target for some toxic xenobiotics and how this could be assessed.

4. Using at least two examples, review the role of toxicity testing in the development of a new drug.

5. Review the role xenobiotics play in transforming a normal cell into a cancer cell.

6. Using specific examples review the role of heavy metals in environmental toxicology.

End of Paper

PP6012 Toxicology Online Theory Exam

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